Mesothelioma causes

In general, cancer begins with a genetic mutation that turns normal, healthy cells into abnormal cells. Healthy cells grow and multiply at a set rate, eventually dying at a set time. Abnormal cells grow and multiply out of control, and they don't die. The accumulating abnormal cells form a mass (tumor). Cancer cells invade nearby tissues and can break off from an initial tumor to spread elsewhere in the body (metastasize).

It isn't clear what causes the initial genetic mutation that leads to mesothelioma, though researchers have identified factors that may increase the risk. It's likely that cancers form because of an interaction between many factors, such as inherited conditions, your environment, your health conditions and your lifestyle choices.

Mesothelioma signs and symptoms

Signs and symptoms of mesothelioma vary depending on where the cancer occurs.

Pleural mesothelioma signs and symptoms may include:

• Shortness of breath
• Painful breathing
• Chest pain under the rib cage
• Unusual lumps of tissue under the skin on your chest
• Unexplained weight loss
• Dry (nonproductive) cough

Peritoneal mesothelioma signs and symptoms may include:

• Abdominal pain
• Abdominal swelling
• A change in your bowel habits, such as more frequent diarrhea or constipation
• Lumps of tissue in the abdomen
• Unexplained weight loss

Signs and symptoms of pericardial mesothelioma and mesothelioma of the tunica vaginalis are unclear. These forms are so rare that not much information is available. Mesothelioma of the tunica vaginalis may be first detected as a mass on a testicle. Pericardial mesothelioma signs and symptoms may include difficulty breathing and fever.

Signs and symptoms of mesothelioma that has spread to other parts of the body include:

• Pain in the area where cancer has spread
• Difficulty swallowing
• Swelling in the neck and face

Mesothelioma info

Mesothelioma is a type of cancer. It is a cancer of mesothelial cells. These cells cover the outer surface of most of our internal body organs, forming a lining that is sometimes called the mesothelium. So this is where this type of cancer gets its name.
The tissues lining (or covering) the lungs are called the pleura. There are two pleura. These can be called pleural membranes. The gap between them is called the pleural space . The pleura are fibrous sheets. They help to protect the lungs. They produce a lubricating fluid that fills the gap between the two pleura. This helps the lungs to move smoothly in the chest when they are inflating and deflating as we breathe.
Mesothelioma is most often diagnosed in the pleura. This is known as pleural mesothelioma. Because it is so close, pleural mesothelioma can also affect the sheet of tissue covering the heart - the pericardium. Doctors call the pericardium the lining, although it is on the outside of the heart. It protects the heart and allows it to move smoothly within the sac that surrounds it. So it does much the same job for the heart as the pleura do for the lungs.
The peritoneum
The tissue lining the abdomen is called the peritoneum. It helps to protect the contents of the abdomen. It also produces a lubricating fluid. This helps the organs to move smoothly inside the abdomen as we move around.
Mesothelioma of the tissues lining the abdominal cavity is known as peritoneal mesothelioma. It is much less common than pleural mesothelioma.
It is unusual for mesothelioma to spread to other parts of the body. But if it does, it does not usually cause troublesome symptoms.
Benign mesothelioma
There is a form of non cancerous (benign) mesothelioma that can develop in the lining of the lungs, or in the lining of the reproductive organs. It can occur in either men or women.

Where can I find information on living with mesothelioma?
Mesothelioma Aid is a good website for resource for families dealing with mesothelioma. It includes advice and referrals to other resources for coping with cancer, caregiving, financial challenges, and support groups. Alternatively, contact us here at Mesothelioma Web for help finding resouces for living with this disease.

How long does it take after exposure for the disease to show up?
People exposed in the 1940s, 50s, 60s, and 70s are now being diagnosed with mesothelioma because of the long latency period of asbestos disease.
How do you get Mesothelioma?
Most people with malignant mesothelioma have worked on jobs where they breathed asbestos. Others have been exposed to asbestos in a household environment, often without knowing it. More about the different ways in which people have been exposed to asbestos.

Mesothelioma

 

People diagnosed with this disease are often told the expected survival rate is only eight to twelve months. However, specialists in treating malignant mesothelioma at the leading cancer centers often have better statistics. For instance, the five-year survival rate has approached 40% for selected patients of Dr. David Sugarbaker at Brigham and Women's Center in Boston. To qualify for Dr. Sugarbaker's treatment you must meet certain criteria. One of them is being in the early stages of the disease, so time is of the essence.
 

Diagnostic Procedures

Thoracoscopy enables a physician to evaluate the pleural cavity and to conduct multiple tissue biopsies under direct vision. In up to 98% of cases, a definitive diagnosis can be obtained. Often, chemical pleurodesis aimed at relieving the accumulation of fluid in the intrapleural space, can be accomplished during the same procedure. It is also possible to gauge the extent of the tumor, and make a determination of surgical resectability. While less invasive than an open biopsy, it can only be performed on patients where tumor has not obliterated the pleural space.
VATS, or video-assisted thoracic surgery is an alternative to thoracoscopy, although because of its more invasive nature, concerns of tumor seeding increase. By utilizing small incisions, the physician can view the pleural space with the assistance of a camera, and obtain sufficient tissue samples for analysis by a pathologist. Extent of the tumor ( i.e., pleural involvement, chest wall invasion) may also determined, and recommendation as to the type of debulking procedure necessary can be made at this time. However, specialists in treating malignant mesothelioma at the leading cancer centers often have better statistics. For instance, the five-year survival rate has approached 40% for selected patients of Dr. David Sugarbaker at Brigham and Women's Center in Boston. To qualify for Dr. Sugarbaker's treatment you must meet certain criteria. One of them is being in the early stages of the disease, so time is of the essence.
In January 2007, the Food and Drug Administration (FDA) approved the MESOMARK assay to help monitor response to treatment in epithelial and bi-phasic malignant mesothelioma patients. A specific protein, or biomarker, called Soluble Mesothelin-Related Peptide (SMRP), may be released into the blood by mesothelioma cancer cells. By measuring the amount of SMRP in a blood sample, doctors may be able to better monitor a patient's progress. Based on the limited amount of data currently available, use of this test may be beneficial, but effectiveness has not been determined at this time. The MESOMARK blood test has NOT yet been approved for the early diagnosis of mesothelioma.
Those wishing to take part in MESOMARK testing will be asked to provide one or more samples of blood. The blood samples will then be sent to a national reference laboratory for testing. In conjunction with other clinical and laboratory data obtained by your doctor, decisions regarding your treatment and care may be simplified. You may discontinue testing at any time.

Wild mushroom can fight prostate cancer

Israeli scientists claim that a wild mushroom, used in traditional Chinese medicine for a century, could treat prostate cancer, the University of Haifa said Friday.Researchers at the university in northern Israel said they found molecules in the Ganoderma lucidum mushroom, commonly known as the reishi, which help supress some mechanisms involved in the progression of prostate cancer.
"We already knew the mushroom could impede the development of cancer by affecting the immune system. The in-vitro trials we have done show that it attacks the cancer cells directly," chief researcher Ben Zion Zaidman told AFP."These results give rise to hope about developing medication to treat prostate cancer," he said of research carried out to date only in Petri dishes. The research still has to be tested on animals.The reishi is found only in remote, wild areas, preferring a habitat of rotting plum tree trunks, sometimes oak trees, in heavily forested mountain areas.The Chinese have tried to grow reishi mushrooms for centuries, but it was only in the early 1970s that Japanese experts managed to cultivate them.Prostate cancer is one of the most common forms of cancer among men, with more than 543,000 cases diagnosed worldwide each year. Israeli Prime Minister Ehud Olmert announced in October that he is suffering from prostate cancer and is expected to undergo surgery in the new year